Electrochemical reactions of copper complexes with Aβ(11-16) and pAβ(11-16) in two different electrolytes

This data set contains cyclic voltammetry redox data from the reaction of copper complexes of the N-truncated β-amyloids Aβ(11-16) and pAβ(11-16) in two different electrolyte solutions and at a wide range of pH.

The data obtained in physiological pH (pH ~ 7.4) as well as lover and higher pH show that Aβ(11‑16)-Cu(II) complex underwent both Cu(II)/Cu(III) oxidation and Cu(II)/Cu(I) reduction reactions, but anodic and cathodic processes could be recorded only at very high and very low potentials, which causes this complex to be redox silent in the human body. The cyclisation of glutamic acid to pyroglutamic acid removed the ATCUN type binding properties, resulting in lower affinity to Cu(II) ions and a strikingly different electrochemical response. Voltammetry (cyclic and differential pulse) of pAβ(11-16)-Cu(II) complexes showed an additional electrochemical process, related to the Cu(I)/Cu(II) cycle, enabled by insufficient stabilisation of the Cu(II) redox state by pAβ(11-16).