High-Pressure Dielectric Spectroscopic Studies of Amorphous CBD: Investigating Molecular Dynamics and Physical Stability Under Manufacturing Conditions of the Pharmaceuticals

Objectives: This study highlighted the key role played by high-pressure (HP) dielectric spectroscopic measurements of amorphous CBD to probe the molecular dynamics in order to examine the physical stability of the drug. The pharmacological properties of CBD assure that this can be a promising drug for the pharmaceutical industry. Hence, it is important to check the physical stability under elevated temperature and pressure conditions to understand the behavior of the drug under manufacturing conditions. Methods: This research investigated the molecular dynamics at various temperatures and pressures. We utilized the HP dielectric studies which are considered as an advanced and sensitive tool to determine both the molecular dynamics and the phase transformations. Results: This paper discusses the physical stability by analyzing the behavior of structural relaxation and crystallization tendencies of the amorphous drug under ambient and elevated pressure conditions. This study verified that amorphous CBD is highly physically stable at storage and elevated temperature conditions under ambient pressure. Conclusions: Accordingly, we examined the physical stability under elevated pressures at storage temperature, and we observed that the compression induced the crystallization of amorphous CBD. The breaking of weak hydrogen bonds present in the CBD might be the reason for this destabilization at elevated pressures. The least physical stability at high-pressure conditions was also confirmed by the broadening of the α-relaxation peak at high pressures.