A therapeutic potential of nicotine: reassessing the current paradigm of nicotine pharmacotherapy, literature review.

Introduction: Nicotine is a widely known alkaloid synthesized from tobacco plants, being a main constituent of tobacco smoke and cigarettes. Nicotine has also gained eminence as the therapeutic option in managing smoking cessation and even other health conditions. However, the therapeutic potential of nicotine in other diseases has yet to be completely assessed. This information void stems from an inherent aversion from researchers in assessing nicotine’s risk-benefit, due to its toxicities. We present information on the current body of evidence relating to non-traditional therapeutic applications of nicotine to fill this literature void. The purpose of this work is to present current literature on the therapeutic uses of nicotine in treating various diseases. Methods: Electronic search in PubMed for relevant research relating to the therapeutic potential of nicotine in various diseases. Results/conclusions: Nicotine has gained therapeutic significance as an active compound of the nicotine replacement therapy. Research show nicotine may have other therapeutic applications in some diseases. We discussed application of nicotine in diminished prevalence of Parkinson’s disease, decreasing symptoms of the Tourette’s syndrome, psychiatric diseases like chizophrenia, depression and management of pain. We also reviewed nicotine dosing, type of formulations, and compliance which are crucial factors in the therapeutic applications of nicotine.